PhD title: Inhibition of adipose tissue lipolysis during exercise to enhance the effectiveness of a walking programme to improve insulin sensitivity in people with pre-diabetes.
PhD start date: 14th November 2018
Project description: For my first project I will investigate GLUT4 translocation during a hyperinsulinemic-euglycemic clamp (HEC) to show that with high free fatty acid availability, GLUT4 translocation in skeletal muscle is impaired. My second study and third study will investigate whether a novel combined exercise and pharmacological intervention can improve insulin sensitivity and glycemic control in people with pre-diabetes.
Biography: I have been at LJMU for the past 7 years in the Sport and Exercise department, completing both my undergraduate degree followed by my MSc in Exercise Physiology. I am now in the final year of my PhD. Outside of academia, I enjoy running, and really good coffee.
Degrees
2021, Liverpool John Moores University, United Kingdom, PhD - Exercise Metabolism
2018, Liverpool John Moores University, United Kingdom, Master of Science in Exercise Physiology - Distinction
2017, Liverpool John Moores University, United Kingdom, Bachelor of Science in Sport and Exercise Science - 2:1
Journal article
Barrett JS, Crozier A, Cuthbertson DJ, Strauss JA, Wagenmakers AJM, Shepherd SO. 2024. A free-living, walking-based, exercise programme, with exercise timed relative to breakfast, to improve metabolic health in people living with overweight and obesity: A feasibility study Verdijk L. PloS one, 19 DOI Author Url Publisher Url Public Url
Barrett JS, Strauss JA, Chow LS, Shepherd SO, Wagenmakers AJM, Wang Y. 2024. GLUT4 localisation with the plasma membrane is unaffected by an increase in plasma free fatty acid availability Lipids in Health and Disease, 23 :1-13 DOI Author Url Publisher Url Public Url
BARRETT JS, SHEPHERD SO, WAGENMAKERS A, CUTHBERTSON D, STRAUSS J. 2022. 3-LB: A Free-Living Walking-Based Exercise Programme Improves HbA1c in Individuals with Obesity, with Additional Benefits of Nutritional Status on Metabolic Health Diabetes, 71 DOI Publisher Url
Barrett J, Whytock KL, Strauss JA, Wagenmakers AJM, Shepherd SO. 2022. High intramuscular triglyceride turnover rates and the link to insulin sensitivity: Influence of obesity, type 2 diabetes and physical activity. Applied Physiology, Nutrition, and Metabolism, DOI Author Url Publisher Url Public Url
Malik Z, Bowden Davies K, Hall E, Barrett J, Pullinger S, Erskine RM, Shepherd SO, Iqbal Z, Edwards BJ, Burniston JG. 2020. Diurnal differences in human muscle isometric force and rate of force development in vivo are associated with differential phosphorylation of sarcomeric M-band proteins. Proteomes, 8 DOI Author Url Publisher Url Public Url
preprint
Stansfield BN, Barrett JS, Bennett S, Stead CA, Pugh J, Shepherd SO, Strauss JA, Louis J, Close GL, Lisboa PJ, Burniston JG. 2024. Turnover rates of human muscle proteins in vivo reported in fractional, mole and absolute units Cold Spring Harbor Laboratory DOI Publisher Url
Thesis/Dissertation
Barrett J. 2023. The Importance of Intramuscular Triglyceride Turnover on Skeletal Muscle Insulin Sensitvity Shepherd S, Strauss J, Wagenmakers A, Cuthbertson D. Public Url
Conference publication
Burniston J, Barrett J, Bennett S, Stead C, Louis J, Close G, Lisboa P. 2020. Dynamic Proteome Profiling of Protein Fractional and Molar Synthesis Rates in Human Muscle
Conference presentation:
The effects of chronic low frequency stimulation on the synthesis and degradation of Creatine Kinase in rat tibialis anterior., BASES Student Conference 2017, Plymouth, Oral presentation. 2017